It’s a no go for ABC’s midseason series “Single With Parents.”

ABC and ABC Studios on Wednesday pulled the plug on the comedy over creative differences with creator Kristin Newman and the rest of the show’s producing team.

The ABC Studios/DreamWorks-produced “Single” — in which Alyssa Milano juggles her dysfunctional family, friends and boss — was one of five pilots ordered in August to series for midseason.

However, production on the project had been postponed several times over disagreements about the show’s creative direction.

Ultimately, the disagreements could not be resolved, and ABC on Wednesday opted not to proceed with “Single” beyond the pilot.